What Is Polivy?

Are you curious to know what is polivy? You have come to the right place as I am going to tell you everything about polivy in a very simple explanation. Without further discussion let’s begin to know what is polivy?

What Is Polivy?

In the ever-evolving landscape of cancer treatment, breakthrough therapies are continually emerging, offering hope and improved outcomes for patients. One such advancement is Polivy, a novel medication designed to target and combat specific types of lymphoma. In this blog post, we will explore what Polivy is, how it works, and its role in the treatment of lymphoma.

Understanding Lymphoma

Before delving into Polivy, it’s essential to understand lymphoma. Lymphoma is a cancer that affects the lymphatic system, a key component of the body’s immune system. It originates in lymphocytes, a type of white blood cell, and can occur in various forms, with the two most common types being Hodgkin lymphoma and non-Hodgkin lymphoma (NHL).

Lymphoma is characterized by the abnormal growth of lymphocytes, leading to the formation of tumors in lymph nodes and other lymphatic tissues. The disease can manifest in different subtypes, each with unique characteristics and treatment approaches.

What Is Polivy?

Polivy (generic name: polatuzumab vedotin-piiq) is a targeted therapy approved by the U.S. Food and Drug Administration (FDA) in June 2019 for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). DLBCL is the most common form of NHL and is characterized by fast-growing, large B-cells.

How Polivy Works?

Polivy belongs to a class of medications known as antibody-drug conjugates (ADCs). It combines an antibody with a potent chemotherapy drug, creating a highly targeted therapeutic agent. The antibody component of Polivy specifically binds to a protein called CD79b, which is found on the surface of B-cell lymphoma cells.

Once Polivy binds to CD79b, it is internalized by the cancer cell. This internalization triggers the release of the chemotherapy drug payload, which directly attacks and kills the lymphoma cell. The targeted approach of Polivy minimizes damage to healthy cells, reducing the side effects often associated with traditional chemotherapy.

Clinical Benefits Of Polivy

Polivy has shown promising results in clinical trials, demonstrating its efficacy in treating relapsed or refractory DLBCL when used in combination with other medications. Some key clinical benefits of Polivy include:

  1. Improved Response Rates: Patients receiving Polivy in combination with chemotherapy have shown higher response rates compared to those receiving chemotherapy alone.
  2. Extended Progression-Free Survival: Polivy has been associated with longer periods of progression-free survival, meaning the disease remains stable or in remission for a more extended period.
  3. Increased Overall Survival: Some studies have indicated improved overall survival rates in patients treated with Polivy.
  4. Reduced Toxicity: The targeted nature of Polivy’s action reduces the side effects typically associated with traditional chemotherapy, such as nausea and hair loss.


Polivy represents a significant advancement in the treatment of relapsed or refractory DLBCL, offering new hope to patients facing this aggressive form of lymphoma. Its targeted approach, combined with conventional chemotherapy, has shown promising results in clinical trials, improving response rates and extending survival. As research continues and medical science evolves, medications like Polivy demonstrate the power of innovation in the fight against cancer, offering the potential for improved outcomes and a higher quality of life for those affected by this disease.

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Is Polivy A Chemo Drug?

POLIVY is a type of medicine called an antibody-drug conjugate, or ADC. POLIVY is designed to work differently from traditional chemotherapies because it has the ability to find dividing B cells, including cancerous B cells. Almost all B cells (including cancerous ones) have a marker on their surface called CD79b.

What Is The Drug Polivy Used For?

Polivy is a cancer medicine used to treat adults with diffuse large B-cell lymphoma (DLBCL) whose cancer has returned or has stopped responding to other treatments and who cannot have a bone-marrow transplantation. It is used in combination with two other medicines, bendamustine and rituximab.

What Is The Active Ingredient In Polivy?

Polivy contains the active ingredient called polatuzumab vedotin. Polivy belongs to a group known as anti-neoplastic (or anti-cancer) agents.

Is Polivy Approved By The Fda?

On April 19, 2023, the FDA approved polatuzumab vedotin-piiq, brand name Polivy, with a rituximab product, cyclophosphamide, doxorubicin, and prednisone for adult patients who have previously untreated diffuse large B-cell lymphoma, not otherwise specified, or high-grade B-cell lymphoma and who have an International …

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